An MCMC Algorithm for Target Estimation in Real-Time DNA Microarrays

An MCMC Algorithm for Target Estimation in Real-Time DNA Microarrays

DNA microarrays detect the presence and quantify the amounts of nucleic acid molecules of interest. They rely on a chemical attraction between the target molecules and their Watson-Crick complements, which serve as biological sensing elements (probes). The attraction between these biomolecules leads to binding, in which probes capture target analytes. Recently developed realtime DNA microarrays...

Real-time DNA microarrays: reality check.

DNA microarrays are plagued with inconsistent quantifications and false-positive results. Using established mechanisms of surface reactions, we argue that these problems are inherent to the current technology. In particular, the problem of multiplex non-equilibrium reactions cannot be resolved within the framework of the existing paradigm. We discuss the advantages and limitations of changing t...

An Algorithm for Real - time

Missing value estimation methods for DNA microarrays

MOTIVATION Gene expression microarray experiments can generate data sets with multiple missing expression values. Unfortunately, many algorithms for gene expression analysis require a complete matrix of gene array values as input. For example, methods such as hierarchical clustering and K-means clustering are not robust to missing data, and may lose effectiveness even with a few missing values....

An Automatic Real Time Impedance Matching System for Use in an RF Electrostatics Accelerator Ion Source